China (Mainland)
25-hYdroxycholesterol CAS NO.2140-46-7 CAS NO.2140-46-7
- Min.Order: 1 Gram
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
- 25-Hydroxycholesterol (not deuterated)
- 2140-46-7
Quick Details
- ProName: 25-hYdroxycholesterol CAS NO.2140-46-7
- CasNo: 2140-46-7
- Molecular Formula: C27H46O2
- Appearance: white powder
- Application: Eldecalcitol intermediate
- DeliveryTime: in stock/ promptly
- PackAge: inquiry
- Port: Shanghai
- ProductionCapacity: 100 Metric Ton/Month
- Purity: 98%
- Storage: in stock/promptly
- Transportation: fedex, dhl, other express,by sea or by...
- LimitNum: 1 Gram
- Moisture Content: according to COA
- Impurity: according to COA
Superiority
Details
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Description
25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types. It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases. Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.
| Item | Standard | Test Results | |
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Identification |
A.H-NMR:Comply with the structure |
Complies |
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B.LC-MS:Comply with the structure |
Complies |
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C.The IR spectrum of sample should be identical with that of reference standard; |
Complies |
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D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
Complies |
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Crystallinity |
meets the requirements. |
Complies |
|
|
Loss on drying |
≤2.0% |
0.19% |
|
|
Heavy metals |
≤10 ppm |
<10ppm |
|
|
Water |
≤1.0% |
0.1% |
|
|
Sulphated ash |
≤0.5%, determined on 1.0 g. |
0.009% |
|
|
Related substances |
Unspecified impurities: for each impurity |
≤0.10% |
<0.10% |
|
Total Impurity |
≤0.5% |
0.18% |
|
|
Purity |
≥99.0% |
99.7% |
|
|
Assay |
99.0%~101.0% (anhydrous substance). |
99.8% |
|
|
Microbiological Analysis |
|||
|
Total plate count |
≤1000cfu/g |
Complies |
|
|
Yeast and Moulds |
≤100cfu/g |
Complies |
|
|
E. Coli. |
Absent |
Negative |
|
|
Salmonella |
Absent |
Negative |
|
|
S.aureus |
Absent |
Negative |
|
|
Storage |
Preserve in well-closed, light-resistant and airtight containers. |
Complies |
|